The research in our laboratory focuses on the development of synthetic methods and strategies for preparation of structurally non-trivial small molecules for applications in biomedical research. Our lab is part of an interdisciplinary research platform - Center of Biomolecular and Cellular Engineering - within the International Clinical Research Centre of St. Anne´s University Hospital in Brno and Mayo Clinic in Rochester, Minnesota (USA). Research funding is provided through national and international resources: FP7, EU-Structural Funds, Grant Agency of the Czech Republic, Grant Agency for Health Research of the Czech Republic, Alfred Bader (private support) and Masaryk University.
Selective kinase inhibitors
Modulators of adenylyl cyclases
Inhibitors of DNA repair pathways
Small-molecules probes of cell differentiation
Fluorescent probes for biological systems